Hiroshi Miwa

Hiroshi Miwa, MD., Ph,D.

Special Associate Professor
Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine

Address

2-174, Edobashi, Tsu, Mie, 514-8507
Phone +59-231-5187, Fax +59-231-5276
E-mail: hmiwa@med.mie-u.ac.jp

Profiles and Research Field

After the clinical and experimental experiences in hematology, he joined the Department of Personalized Cancer Immunotherapy from April, 2018. He is working on CAR-T therapy for cancer including leukemia, and is interested in optimization of CAR in metabolic milieu.

Recent Publications

  1. Goto M, Miwa H, Shikami M, Tsunekawa-Imai N, Suganuma K, Mizuno S, Takahashi M, Mizutani M, Hanamura I, Nitta M: Importance of glutamine metabolism in leukemia cells by energy production through TCA cycle and by redox homeostasis. Cancer Invest 32: 241-247, 2014
  2. Mineaki Goto, Hiroshi Miwa, Kazuto Suganuma, Norikazu Tsunekawa-Imai, Masato Shikami, Motonori Mizutani, Shohei Mizuno, Ichiro Hanamura, Masakazu Nitta: Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress. BMC Cancer 14: 76, 2014
  3. Norikazu Tsunekawa-Imai, Hiroshi Miwa, Masato Shikami, Kazuto Suganuma, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Motonori Mizutani, Tomohiro Horio, Hiroko Komatsubara, Mayuko Gotou, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta: Growth of xenotransplanted leukemia cells is influenced by diet nutrients and is attenuated with 2-deoxyglucose. Leuk Res 37: 1132-1136, 2013
  4. Hiroshi Miwa, Masato Shikami, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Norikazu Tsunekawa-Imai, Takamasa Ishikawa, Motonori Mizutani, Tomohiro Horio, Mayuko Gotou, Hidesuke Yamamoto, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta: Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep 29: 2053-2057, 2013
  5. Kazuto Suganuma, Hiroshi Miwa, Norikazu Imai, Masato Shikami, Mayuko Gotou, Mineaki Goto, Shohei Mizuno, Miyuki Takahashi, Hidesuke Yamamoto, Akihito Hiramatsu, Motohiro Wakabayashi, Masaya Watarai, Ichiro Hanamura, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta : Energy metabolism of leukemia cells : glycolysis vs oxidative phosphorylation. Leuk Lymphoma 51: 2112-2119, 2010
  6. Imai N, Miwa H, Shikami M, Suganuma K, Gotoh M, Hiramatsu A, Wakabayashi M, Watarai M, Hanamura I, Imamura A, Mihara H, Shitara K, Shibuya M, Nitta M : Growth inhibition of AML cells with specific chromosome abnormalities by monoclonal antibodies to receptors for vascular endothelial growth factor. Leuk Res 33: 1650-1657, 2009
  7. Norikazu Imai, Masato Shikami, Hiroshi Miwa, Kazuto Suganuma, Akihito Hiramatsu, Masaya Watarai, Atsushi Satoh, Masato Itoh, Akira Imamura, Hidetsugu Mihara, Masakazu Nitta : t(8;21) acute myeloid leukaemia cells are dependent on vascular endothelial growth factor (VEGF) / VEGF receptor type2 pathway and phosphorylation of Akt. Br J Haematol 135: 673-682, 2006
  8. A. Hiramatsu, H. Miwa, M. Shikami, T. Ikai, E. Tajima, H. Yamamoto, N. Imai, A. Hattori, T. Kyo, M. Watarai, K. Miura, A. Satoh, M. Itoh, A. Imamura, H. Mihara, Y. Katoh, M. Nitta : Disease-specific expression of VEGF and its receptors in AML cells: possible autocrine pathway of VEGF/ type1 receptor of VEGF in t(15;17) AML and VEGF/ type2 receptor of VEGF in t(8;21) AML. Leuk Lymphoma 47: 89-95, 2006
  9. Toshiko Ikai, Hiroshi Miwa, Masato Shikami, Akihito Hiramatsu, Emi Tajima, Hidesuke Yamamoto, Norikazu Imai, Akiko Hattori, Kazuhiro Nishii, Kazuhisa Miura, Atsushi Satoh, Masato Itoh, Akira Imamura, Hidetsugu Mihara, Yoshiro Katoh, Masakazu Nitta : Placenta growth factor stimulates the growth of Philadelphia chromosome positive acute lymphoblastic leukaemia cells by both autocrine and paracrine pathways. Eur J Haematol 75: 273-279, 2005
  10. Wakabayashi M, Miwa H, Shikami M, Hiramatsu A, Ikai T, Tajima E, Yamamoto H, Miura K, Satoh A, Itoh M, Imamura A, Mihara H, Katoh Y, Nitta M : Autocrine pathway of angiopoietins-Tie2 system in AML cells: association with phosphatidyl-inositol 3 kinase. The Hematol J 5: 353-360, 2004
  11. Watarai M, Miwa H, Shikami M, Sugamura K, Wakabayashi M, Satoh A, Tsuboi K, Imamura A, Mihara H, Katoh Y, Kita K, Nitta M : Expression of endothelial cell-associated molecules in AML cells. Leukemia 16: 112-119, 2002