Takuma Kato

Takuma Kato, Ph.D.

Associate Professor, Department of Immunoloy, Mie University Graduate School of Medicine

Address

2-174, Edobashi, Tsu, Mie, 514-8507
Phone +59-231-5187, Fax +59-231-5276
katotaku@med.mie-u.ac.jp

Key words

CAR-T cell therapy, Protumor function of IL-17

Research title

Recent Publication

  1. Akahori Y, Wang L, Yoneyama M, Seo N, Okumura S, Miyahara Y, Amaishi Y, Okamoto S, Mineno J, Ikeda H, Maki T, Fujiwara H, Akatsuka Y, Kato T, Shiku H. (2018）Antitumor activity of CAR-T cells targeting the intracellular oncoprotein WT1 can be enhanced by vaccination. Blood. 2018;132:1134-1145. 
  2. Hori T, Uemoto S, Saito K, Kuribayashi K, Hori Y, Kato T. (2017) Challenge of ex vivo-stimulated CD4(+)CD25(+) regulatory T cell-mediated alloantigen-specific immunosuppression by murine cardiac transplantation. Transpl Immunol 40, 72-73. 
  3. Linan Wang, Ning Ma, Sachiko Okamoto, Yasunori Amaishi, Eiichi Sato, Naohiro Seo, Junichi Mineno, Kazutoh Takesako, Takuma Kato and Hiroshi Shiku. (2016) Efficient Tumour Regression by Adoptively Transferred CEA-Specific CAR-T Cells Associated with Symptoms of Mild Cytokine Release Syndrome.  Oncoimmunol In press. 
  4. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Kato, T. (2015) Alloantigen-specific CD4+ regulatory T cells induced in vivo by ultraviolet irradiation after alloantigen immunization require interleukin-10 for their induction and activation, and flexibly mediate bystander immunosuppression of allograft rejection. Transplant Immunology, 1-8. 
  5. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Iida, T., Yagi, S., Kato, T. (2015) Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity. World journal of transplantation 5, 11-8. 
  6. Nishikawa, K., Seo, N., Torii, M., Ma, N., Muraoka, D., Tawara, I., Masuya, M., Tanaka, K., Takei, Y., Shiku, H., Katayama, N., Kato, T. (2014) Interleukin-17 Induces an Atypical M2-Like Macrophage Subpopulation That Regulates Intestinal Inflammation. PLoS one 9, e108494. 
  7. Hori, T., Kuribayashi, K., Saito, K., Wang, L., Torii, M., Uemoto, S., Kato, T. (2014) Induction of alloantigen-specific CD4+ T regulatory Type 1 cells by alloantigen immunization and ultraviolet-B irradiation: a pilot study in murine transplantation models with skin and cardiac allografts. Ann Transplant 19, 519-36. 
  8. Muraoka, D., Nishikawa, H., Noguchi, T., Wang, L., Harada, N., Sato, E., Luescher, I., Nakayama, E., Kato, T., Shiku, H. (2013) Establishment of animal models to analyze the kinetics and distribution of human tumor antigen-specific CD8(+) T cells. Vaccine 31, 2110-8. 
  9. Kato, T., Tada-Oikawa, S., Wang, L., Murata, M., Kuribayashi, K. (2013) Endocrine disruptors found in food contaminants enhance allergic sensitization through an oxidative stress that promotes the development of allergic airway inflammation. Toxicology and Applied Pharmacology 273, 10-18. 
  10. Hirayama, M., Nishikawa, H., Nagata, Y., Tsuji, T., Kato, T., Kageyama, S., Ueda, S., Sugiyama, D., Hori, S., Sakaguchi, S., Ritter, G., Old, L. J., Gnjatic, S., Shiku, H. (2013) Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes. European Journal of Immunology 43, 989-1000. 
  11. Noguchi, T., Kato, T., Wang, L., Maeda, Y., Ikeda, H., Sato, E., Knuth, A., Gnjatic, S., Ritter, G., Sakaguchi, S., Old, L. J., Shiku, H., Nishikawa, H. (2012) Intracellular Tumor-Associated Antigens Represent Effective Targets for Passive Immunotherapy. Cancer Research 72, 1672-1682. 
  12. Iwamura, K., Kato, T., Miyahara, Y., Naota, H., Mineno, J., Ikeda, H., Shiku, H. (2012) siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions. Gene therapy 19, 959-66. 
  13. Hori, T., Uemoto, S., Chen, F., Baine, A.-M., Gardner, L., Hata, T., Kuribayashi, K., Kato, T., Saito, K., Wang, L., Torii, M., Endo, K., Jobara, K., Sulistiono, B., Nguyen, J. H. (2012) Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9. Ann Gastroenterol 25, 345. 
  14. Toda, M., Wang, L., Ogura, S., Torii, M., Kurachi, M., Kakimi, K., Nishikawa, H., Matsushima, K., Shiku, H., Kuribayashi, K., Kato, T. (2011) UV irradiation of immunized mice induces type 1 regulatory T cells that suppress tumor antigen specific cytotoxic T lymphocyte responses. International journal of cancer 129, 1126-36. 
  15. Kato, T. and Wang, L. (2011) UV-Induced Immune Suppression that Promotes Skin Cancer Development and Progression. 
  16. Kato, T. (2011) Stat3-driven cancer-related inflammation as a key therapeutic target for cancer immunotherapy. Immunotherapy 3, 587-90. 
  17. Hori, T., Kaido, T., Oike, F., Ogura, Y., Ogawa, K., Yonekawa, Y., Hata, K., Kawaguchi, Y., Ueda, M., Mori, A., Segawa, H., Yurugi, K., Takada, Y., Egawa, H., Yoshizawa, A., Kato, T., Saito, K., Wang, L., Torii, M., Chen, F., Baine, A.-M. T., Gardner, L. B., Uemoto, S. (2011) Thrombotic microangiopathy-like disorder after living-donor liver transplantation: A single-center experience in Japan. World journal of gastroenterology : WJG 17, 1848-57. 
  18. Wang, L., Saito, K., Toda, M., Hori, T., Torii, M., Ma, N., Katayama, N., Shiku, H., Kuribayashi, K., Kato, T. (2010) UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10. Immunobiology 215, 124-32. 
  19. Uno, K., Okuno, K., Kato, T., Tada-Oikawa, S., Kan, N., Saotome, H., Yagi, K., Hamuro, J. (2010) Pre-operative intracellular glutathione levels of peripheral monocytes as a biomarker to predict survival of colorectal cancer patients. Cancer Immunology, Immunotherapy 59, 1457-65. 
  20. Torii, M., Wang, L., Ma, N., Saito, K., Hori, T., Sato-Ueshima, M., Koyama, Y., Nishikawa, H., Katayama, N., Mizoguchi, A., Shiku, H., Yodoi, J., Kuribayashi, K., Kato, T. (2010) Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation. European Journal of Immunology 40, 787-96. 
  21.  Tada-Oikawa, S., Murata, M., Kato, T. (2010) Preferential induction of apoptosis in regulatory T cells by tributyltin: Possible involvement in the exacerbation of allergic diseases. Nippon eiseigaku zasshi Japanese journal of hygiene 65, 530-5. 
  22. Muraoka, D., Kato, T., Wang, L., Maeda, Y., Noguchi, T., Harada, N., Takeda, K., Yagita, H., Guillaume, P., Luescher, I., Old, L. J., Shiku, H., Nishikawa, H. (2010) Peptide vaccine induces enhanced tumor growth associated with apoptosis induction in CD8+ T cells. Journal of immunology (Baltimore, Md : 1950) 185, 3768-76. 
  23. Mitsui, J., Nishikawa, H., Muraoka, D., Wang, L., Noguchi, T., Sato, E., Kondo, S., Allison, J. P., Sakaguchi, S., Old, L. J., Kato, T., Shiku, H. (2010) Two distinct mechanisms of augmented antitumor activity by modulation of immunostimulatory/inhibitory signals. Clinical cancer research : an official journal of the American Association for Cancer Research 16, 2781-91.
  24. Hori, T., Nguyen, J. H., Zhao, X., Ogura, Y., Hata, T., Yagi, S., Chen, F., Baine, A.-M. T., Ohashi, N., Eckman, C. B., Herdt, A. R., Egawa, H., Takada, Y., Oike, F., Sakamoto, S., Kasahara, M., Ogawa, K., Hata, K., Iida, T., Yonekawa, Y., Sibulesky, L., Kuribayashi, K., Kato, T., Saito, K., Wang, L., Torii, M., Sahara, N., Kamo, N., Sahara, T., Yasutomi, M., Uemoto, S. (2010) Comprehensive and innovative techniques for liver transplantation in rats: a surgical guide. World journal of gastroenterology : WJG 16, 3120-32.